DuBois-Reymond's law is associated with which aspect of electrical stimulation?

• A. Rheobase
• B. Chronaxie
• C. Make-break law
• D. Intensity of stimulus

Answer: (C)

Du Bois-Reymond's law highlights how nerve excitation depends on the way the current is delivered, specifically the rapid changes when the current is applied (made) and released (broken). He showed that these make and break transitions can trigger a response in nerve tissue beyond what a steady, continuous current would elicit, so the dynamic onset and offset of stimulation play a key role. This is why the make-break aspect is the best fit. Rheobase and chronaxie describe thresholds for steady-time stimulation, and just the intensity of the stimulus doesn’t capture the importance of how the current is turned on and off.